I suppose this *is* the sort of subject likely to be posted here ;)
That's an interesting approach. Taking it further, no single mind can be sure of anything, except for that it and its thoughts exist. Other beings, mankind, animals, constructions, physics, math, space, this forum, could be complete fantasies. Of course that doesn't seem likely.
Mysticism is based on the idea that enlightenment can be gained through drug use. Of course that sounds to your average Westerner absurd; drugs cause hallucinations. However, Aldous Huxley merged Mysticism with Science in his book 'The Doors Of Perception' in which he proposed that certain drugs such as lysergic acid cause UN-hallucinations rather than hallucinations. That is, rather than percieving things that don't objectively exist, the user perceives things that *do* objectively exist, but are not normally percieved. The universe is infinitely more complex than is generally believed. A huge percentage of the universe is not percieved by humans normally simply because it is not biologically relevant - as a animal, a person's biological goal is to survive and nothing more. Therefore huge amounts of information are filtered out.
Who really knows though, many many people have spent their lives trying to figure it out and never done it.
Tronyn
PS the Matrix is really overrated, and it sucks =p