: She's referring to the point that in Noble Six got canonically referred to as
: a man by Jun in "New Blood". Not a big deal, but would have been
: nice to keep it gender-neutral so the player's choice could have remained
: canon if you chose to play as a woman.

Probably simply how the author decided to write it, but I doubt 343 would have any real issue with pulling a Mass Effect and saying they're just making it neutral as the official canon, because, seriously, there's no real difference either way.